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Medchemexpress LLC Pyridostatin (TFA) | 1472611-44-1 | 1037658 | C33H33F3N8O7 | 25 MG
Supplier: Medchemexpress LLC 25MGHY15176B
Pyridostatin TFA is a G-quadruplex DNA stabilizing agent with a Kd of 490 nM, targeting both DNA and RNA G4s within cells. This selective small molecule promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage and affects proto-oncogene Src.
- Targets DNA and RNA G4s in cells
- Promotes growth arrest in human cancer cells
- Induces replication- and transcription-dependent DNA damage
- Reduces SRC protein levels and cellular motility in breast cancer cells
- Causes neurite retraction, synaptic loss, and dose-dependent neuronal death in cultured primary neurons
- Induces DNA DSBs in cultured primary neurons
- Downregulates BRCA1 protein at the transcriptional level
- High purity: 99.17%
- Solid, white to off-white appearance
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