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Medchemexpress LLC Pyrrolo[2,1-b][1,3]oxazepine-7-carboxamide, octahydro-8,8-dimethyl-4-[[(2S)-2-(methylamino)-1-oxopropyl]ami | 1422180-49-1 | MFCD34469389 | 98.4% | 456.58 g/mol | C25H36N4O4 | 5MG
SDP

Supplier:  Medchemexpress LLC HY1253785MG

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SBP-0636457 is a small-molecule SMAC mimetic and inhibitor of apoptosis protein (IAP) antagonist used for preclinical cancer research. It binds the BIR domains of IAP proteins (Ki = 0.27 μM) and has shown TRAIL-sensitizing activity in cell models, supporting use in both in vitro and in vivo studies.

  • Binds inhibitor of apoptosis proteins with Ki of 0.27 μM.
  • Demonstrated TRAIL-sensitizing activity (EC50 9 nM in MDA-MB-231 cells).
  • High purity suitable for biological assays.
  • Soluble in DMSO (≈45.7 mg/mL) and compatible with several in vivo formulations.
  • Storage recommendations available for solid and solution forms to preserve stability.
  • No cytotoxicity observed in selected breast cancer cell lines up to 20 μM.

Catalog No. 50-002-35084


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