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Medchemexpress LLC Pyrrolopyrimidine (JH-II-127) | 1700693-08-8 | 98.0% | 416.86 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY16936100MG

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JH-II-127 is an orally active, highly potent, selective, and brain-permeable LRRK2 inhibitor. It has IC50s of 6, 2, and 48 nM for wild-type LRRK2, LRRK2-G2019S, and mutant LRRK2-A2016T, respectively. It inhibits Ser935 phosphorylation in all tissues of mice, including the brain, and can be used in the study of Parkinson's syndrome.

  • Orally active
  • Highly potent
  • Selective
  • Brain-permeable
  • Inhibits Ser935 phosphorylation in all tissues of mice, including the brain
  • Can be used in the study of Parkinson's syndrome
  • Appearance: Solid
  • Color: Light yellow to yellow

Catalog No. 50-003-91267


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