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Cayman Chemical PyrvInIumpamoate 100mg
Supplier: Cayman Chemical 31546100 MG
An anthelmintic and anticancer agent; dietary administration reduces worm burden in mouse models of N. dubius, S. obvelata, or A. tetraptera infection (EC50s = 292, 4, and 17 ppm, respectively); lethal to mice at higher concentrations (LC50 = 600 ppm in the diet); induces cytotoxicity in PANC-1 cells cultured in glucose-deficient medium, but not serum- or amino acid-deficient medium or complete medium, at 1 μg/ml; reduces tumor growth in a PANC-1 mouse xenograft model at 100 μg/mouse per day; binds to and activates CK1α at 10 nM; inhibits Wnt signaling (EC50 = ~10 nM in a reporter assay) in a CK1α-dependent manner
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