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Apexbio Technology LLC QNZ (EVP4593) 545380-34-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A42175.1
QNZ (EVP4593 CAS number 545380-34-5) is a quinazoline-derived small molecule inhibitor of the NF- B signaling pathway Originally identified using a luciferase reporter assay in human Jurkat T cells QNZ effectively suppresses PMA/PHA-induced NF- B transcriptional activation (IC50 11 nM) and TNF- production (IC50 7 nM) Additionally QNZ demonstrates anti-inflammatory properties reducing edema formation in a carrageenan-induced rat paw swelling model In Huntington s disease research QNZ improved motor performance in transgenic fly models without toxicity suggesting potential neuroprotective applications
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