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Apexbio Technology LLC Quercetin(Synonyms: Sophoretin, Meletin, Quercetine, 3,3',4',5,7-Pentahydroxyflavone, Quercetol, Xanthaurine), 10mM (in 1mL DMSO), CAS: 117-39-5.
Supplier: Apexbio Technology LLC N18415.1
Quercetin (CAS 117-39-5) is a dietary flavonoid widely found in fruits vegetables nuts tea and red wine exhibiting notable antineoplastic and anti-inflammatory effects It functions primarily as a potent inhibitor of intracellular signaling kinases including PI3K and NF- B and moderately inhibits Akt1/2 with weaker effects on PKC p38 and ERK1/2 pathways Moreover quercetin can elevate cytosolic Ca levels disrupt mitochondrial membrane potential induce cytochrome c release and activate caspases (3 8 and 9) thereby promoting apoptosis through mitochondrial pathways It also affects cell cycle progression and apoptosis via stabilizing and phosphorylating p53 Thus quercetin serves as a valuable tool in cancer research providing insights into chemoprevention mechanisms and therapeutic potentials
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