Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Quinacrine (dihydrochloride) | 69-05-6 | 99.4% | 472.88 | 1 G
Supplier: Medchemexpress LLC HY13735A1G
Quinacrine dihydrochloride, also known as Mepacrine dihydrochloride, is an orally bioavailable antimalarial agent with demonstrated anticancer effects both in vitro and in vivo. It functions by suppressing NF-kB and activating p53 signaling pathways, which ultimately leads to the induction of apoptosis.
- Targets autophagy, mitophagy, parasite, and apoptosis
- Involved in autophagy, anti-infection, and apoptosis pathways
- Inhibits the growth of SGC-7901 cells
- Induces apoptosis in SGC-7901 cells via mitochondria-dependent signaling
- Increases levels of proapoptotic proteins (cytochrome c, Bax, p53)
- Decreases antiapoptotic protein Bcl-2
- Significantly suppresses circulating blast cells in an AML-PS model
- Increases median survival time in AML mouse models
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?