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Medchemexpress LLC Quizartinib | 950769-58-1 | 99.1% | 200 MG
Supplier: Medchemexpress LLC HY13001200MG
Quizartinib is an orally active, highly selective, and potent second-generation type II FLT3 tyrosine kinase inhibitor. It inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells, with IC50s of 4.2 nM and 1.1 nM respectively. This compound can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader, and it induces apoptosis. It is intended for research use only.
- Orally active
- Highly selective and potent type II FLT3 tyrosine kinase inhibitor
- Inhibits wild-type FLT3 and FLT3-ITD autophosphorylation
- Forms PROTAC FLT3 degrader when linked to VHL ligand
- Induces apoptosis
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