Apexbio Technology LLC Quizartinib (AC220) 950769-58-1 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A57935.1

Quizartinib (AC220) is a second-generation small molecule inhibitor specifically targeting FMS-like tyrosine kinase 3 (FLT3) It exhibits potent inhibitory activity against FLT3 kinases harboring internal tandem duplication (ITD) and wild-type forms with reported IC50 values around 1 1 nM and 4 2 nM respectively Quizartinib demonstrates selectivity for FLT3 with minimal inhibition toward other kinases such as KIT PDGFR / RET and CSF-1R In cell-based assays using MV4-11 AML cell lines that express FLT3-ITD quizartinib reduces FLT3 phosphorylation thus inhibiting downstream signaling pathways involved in tumor cell proliferation and survival Quizartinib is utilized primarily in leukemia research to examine FLT3 signaling dependency and resistance mechanisms providing a useful tool for investigating molecular pathways and therapeutic strategies in acute myeloid leukemia (AML)

Catalog No. 50-000-61482