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Apexbio Technology LLC QX 314 chloride 5369-03-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B70155.1
QX 314 chloride (CAS 5369-03-9) is a quaternary lidocaine derivative characterized by low membrane permeability It selectively inhibits voltage-gated sodium (Na sup /sup ) channels on nociceptive neurons when delivered intracellularly Entry into neurons occurs via activation and permeation through the TRPV1 or TRPA1 channel pores often facilitated by co-application with agonists such as capsaicin In nociceptive neurons QX 314 chloride blocks Na sup /sup currents and suppresses excitability whereas it also induces prolonged blockade of motor neuron function This compound is employed in studies of pain signaling selective sensory or motor nerve inhibition and mechanisms of ion channel-mediated drug entry
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