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  8. (R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%

(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%

Catalog No. AAL14325MF
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Description

CAS: 39637-99-5 | C10H8ClF3O2 | 252.62 g/mol

(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is used as a chiral acylating reagent, which is used in the resolution of amino acid enantiomers like 2,5-dimethoxy-4-methylamphetamine. It is also suitable for the determination of the optical composition of compounds extracted from biological fluids.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is used as a chiral acylating reagent, which is used in the resolution of amino acid enantiomers like 2,5-dimethoxy-4-methylamphetamine. It is also suitable for the determination of the optical composition of compounds extracted from biological fluids.

Solubility
Sparingly miscible with water.

Notes
Moisture sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 39637-99-5
Molecular Formula C10H8ClF3O2
Molecular Weight (g/mol) 252.62
MDL Number MFCD00044400
InChI Key PAORVUMOXXAMPL-VIFPVBQESA-N
Synonym unii-81ut10uhv3, r---mtpa-cl, --alpha-methoxy-alpha-trifluoromethyl phenylacetyl chloride, r---alpha-methoxy-alpha-trifluoromethyl phenylacetyl chloride, r-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride, 2r-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride, r---a-methoxy-a-trifluoromethylphenylacetyl chloride, r---alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride, --mtpa-cl, --mosher's acid chloride
PubChem CID 3080792
IUPAC Name (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride
SMILES CO[C@](C(Cl)=O)(C1=CC=CC=C1)C(F)(F)F

Specifications

Density 1.353
Boiling Point 213°C to 214°C
Flash Point 89°C (192°F)
Refractive Index 1.469
Quantity 50 mg
UN Number UN3265
Beilstein 3591565
Sensitivity Moisture sensitive
Merck Index 14,6280
Solubility Information Sparingly miscible with water.
Optical Rotation −137° (Neat)
Formula Weight 252.62
Percent Purity ≥98%
Chemical Name or Material (R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride
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Safety and Handling

Hazard Category H227-H314-H335
Hazard Statement GHS H Statement
H314-H318-H227
Causes severe skin burns and eye damage.
Causes serious eye damage.
Combustible liquid.
Precautionary Statement P210-P235-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c
DOTInformation Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.
TSCA No
Recommended Storage Store at -20°C; Store under Nitrogen
SDS

RUO – Research Use Only

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