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Medchemexpress LLC (R)-BPO-27 | 1415390-47-4 | 99.9% | 548.34 | 1 MG
SDP

Catalog No. 5000401847
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(R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR inhibitor with an IC50 of 4 nM. It inhibits the CFTR current by 50% at 0.53 nM in HEK-293T cells and prevents fluid accumulation in closed midjejunal loops in mice.

  • Potent CFTR inhibitor with an IC50 of 4 nM.
  • Orally active and ATP-competitive.
  • The R enantiomer, (S)-BPO-27 does not affect channel parameters.
  • Exhibits slow metabolism and sustained serum levels for at least 4 hours.
  • Oral bioavailability of ~94% in mice.
  • Solid, white to off-white appearance.

Catalog No. 50-004-01847 Supplier Medchemexpress LLC Supplier No. HY197781MG
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(R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR inhibitor with an IC50 of 4 nM. It inhibits the CFTR current by 50% at 0.53 nM in HEK-293T cells and prevents fluid accumulation in closed midjejunal loops in mice.

  • Potent CFTR inhibitor with an IC50 of 4 nM.
  • Orally active and ATP-competitive.
  • The R enantiomer, (S)-BPO-27 does not affect channel parameters.
  • Exhibits slow metabolism and sustained serum levels for at least 4 hours.
  • Oral bioavailability of ~94% in mice.
  • Solid, white to off-white appearance.

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