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Medchemexpress LLC (R)-BPO-27 | 1415390-47-4 | 99.9% | 548.34 | 1 ML
Supplier: Medchemexpress LLC HY1977810MM/1ML
(R)-BPO-27 is a potent, orally active, and ATP-competitive CFTR inhibitor with an IC50 of 4 nM. It is the R enantiomer of BPO-27, acting from the cytoplasmic side with low membrane permeability. This compound reduces channel open probability and increases mean channel closed time in HEK-293T cells expressing human wild-type CFTR, and is intended for research use only.
- Potent CFTR inhibitor with an IC50 of 4 nM
- Stabilizes CFTR channel closed state at 600 pM
- Effective in inhibiting Cl- current stimulated by cAMP and cGMP agonists
- Provides sustained therapeutic concentrations in the kidney
- Prevents cholera toxin-induced fluid accumulation in intestinal loops
- Achieves approximately 94% oral bioavailability in mice
- Exhibits slow metabolism, maintaining serum levels for over 4 hours
- Shows efficacy in mouse models of cholera and traveler's diarrhea
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