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Cayman Chemical R-CrIzotInIb 50mg
Supplier: Cayman Chemical 1208750 MG
A dual inhibitor of c-Met and ALK (IC50s = 8 and 20 nM, respectively, in a cell-based assay); selective for c-Met and ALK over several other receptor and non-receptor tyrosine kinases, including Ron, Tie2, Abl, LCK, and VEGFR2 (IC50s = 0.08, 0.448, 1.159, 2.741, and >10 µM, respectively); selectively inhibits the proliferation of cancer cell lines with MET amplifications over cancer cell lines with MET or EGFR mutations (IC50s = 5-10, 472-1,284, and 767-787 nM, respectively); induces apoptosis in MET-amplified EBC-1 and NCI H1993 cells at 100 nM; reduces tumor volume in an EBC-1 mouse xenograft model at 25 mg/kg
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