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R&D Systems™ Human/Mouse Ephrin Sampler Pack Protein Sampler Pack

Extensive quality control produces lot-to-lot consistency that instills confidence in results and ensures reproducibility.

Manufacturer:  R&D Systems™ SMPK3

Catalog No. SMPK3

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The Eph receptors represent the largest family of receptor tyrosine kinases (RTK) in the human genome. Their ligands, the ephrins, are also cell surface bound proteins, thereby requiring cell-cell interaction for binding and signaling. The ephrin ligands are divided into two categories: the A class are tethered to the membrane by a GPI anchor, and the B class are transmembrane proteins. Likewise, the receptors are also divided into two categories based on sequence similarity and ligand specificity. Ephrin-A ligands bind EphA receptors and ephrin-B ligands bind EphB receptors, with the exception of EphA4 which binds both A and B-type ligands. Eph/ephrin signaling is involved in vascular development, tissue-border formation, brain boundaries, cell migration, axon guidance, and synaptic plasticity. Eph/ephrin signaling activation generally results in repulsion of cells and often converges on the regulation of the cytoskeleton. Like most RTKs, ligand binding induces forward signaling, where a response occurs in the Eph receptor-containing cell. However, in some circumstances, this family can also exhibit reverse signaling where ephrins act as receptors responding to Eph signals, and ephrins signal back into their host cell.


1 Pack
Ephrin Sampler Pack
Store the unopened product at -20 to -70° C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
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