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Medchemexpress LLC (R)-Ketorolac | 66635-93-6 | 99.7% | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHYB0580B

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(R)-Ketorolac is an orally active Cdc42 and Rac1 inhibitor. It inhibits GTPase and alters ovarian cancer cell behaviors critical for invasion and metastasis. It also ameliorates cancer-associated cachexia.

  • Inhibits growth factor-dependent activation of Cdc42 and Rac1 in SKOV3ip cells with EC50 values of 2.577 μM for Cdc42 and 0.587 μM for Rac1.
  • Decreases numbers and length of filopodia in SKOV3ip cells and reduces their adherence to fibronectin and collagen.
  • Ameliorates cancer-associated cachexia and prolongs survival of C26 tumor-bearing mice.
  • Prevented C26-induced T-lymphopenia.

Catalog No. 50-004-50756


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