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Medchemexpress LLC (R)-Lisofylline | 100324-81-0 | 99.99% | 280.32 | 1 ML
Supplier: Medchemexpress LLC HY109854A100MG
(R)-Lisofylline is the (R)-enantiomer of a Pentoxifylline metabolite with anti-inflammatory properties. It acts as a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 μM and disrupts IL-12 signaling-mediated STAT4 activation. It has potential for research in type 1 diabetes and autoimmune disorders.
- Acts as a lysophosphatidic acid acyltransferase inhibitor.
- Interrupts IL-12 signaling-mediated STAT4 activation.
- Blocks IL-12-driven Th1 differentiation and T cell proliferation.
- Reduces impairment of insulin secretion induced by IL-1β.
- Suppresses IFN-γ production and onset of diabetes in NOD mice.
- Ameliorates experimental allergic encephalomyelitis in mice.
- Improves survival in mice injected with a lethal dose of LPS.
- Ameliorates sepsis-induced lung injury in minipigs.
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