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Medchemexpress LLC (R,R)-GSK321 | 1816272-19-1 | 99.4% | 10 MG
Supplier: Medchemexpress LLC HY12888810MG
(R,R)-GSK321 is an inhibitor of wild-type isocitrate dehydrogenase 1 (WT IDH1) with an IC50 value of 120 nM. This compound also acts as a mutant R132H IDH1 inhibitor and is an isomer of GSK321 with some wild-type cross-reactivity. It has a molecular weight of 501.55 and a chemical formula of C28H28FN5O3. This product appears as a white to off-white solid.
- Inhibits wild-type isocitrate dehydrogenase 1 (WT IDH1)
- IC50 value of 120 nM for WT IDH1
- Acts as a mutant R132H IDH1 inhibitor
- Isomer of GSK321 with some wild-type cross-reactivity
- Dose-dependently decreases reductive glutaminolysis in A-498 cells (0.1-3 μM for 5 hours)
- For research use only, not for patient use
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