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Medchemexpress LLC (R,R)-GSK321 | 1816272-19-1 | 99.4% | 50 MG
Supplier: Medchemexpress LLC HY12888850MG
(R,R)-GSK321 is a potent inhibitor of wild-type isocitrate dehydrogenase 1 (WT IDH1) with an IC50 value of 120 nM. This compound also acts as a mutant R132H IDH1 inhibitor, being an isomer of GSK321 with some wild-type cross-reactivity.
- Potent WT IDH1 inhibitor
- IC50 value of 120 nM for WT IDH1
- Mutant R132H IDH1 inhibitor
- Decreases reductive glutaminolysis in A-498 cells
- For research use only
- Associated with cancer, cancer targeted therapy, and cancer metabolism research
- Classified as a metabolic enzyme/protease and isocitrate dehydrogenase (IDH) inhibitor
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