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Cayman Chemical R1487hydrochlorIde 10mg
Supplier: Cayman Chemical 3147810 MG
An inhibitor of p38α MAPK (IC50 = 10 nM); selective for p38α over p38β MAPK (Kds = 0.2 and 29 nM, respectively), as well as a panel of 306 additional kinases at 10 µM, but does inhibit 11 kinases by >85% at 10 µM; inhibits LPS-induced IL-1β production in isolated human whole blood (IC50 = 170 nM); inhibits LPS-induced production of TNF-α and IL-6 in rats (ED50s = 0.8 and 0.4 mg/kg); reduces yeast-induced hyperalgesia in rats (ED50 = 5.5 mg/kg)
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