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Apexbio Technology LLC R406 841290-81-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A85465.1
R406 (CAS 841290-81-1) is an orally active inhibitor targeting spleen tyrosine kinase (SYK) a non-receptor tyrosine kinase prominently expressed in hematopoietic cells SYK mediates essential signaling upon activation of immune receptors including Fc and B-cell receptors impacting immune responses platelet activation osteoclast differentiation and vascular development By competitively binding to SYK s ATP-binding pocket R406 disrupts SYK-mediated downstream substrate phosphorylation It potently inhibits IgE- and IgG-induced Fc receptor signaling (IC50 56 64 nM) and blocks SYK-dependent B-cell receptor activation (SYK IC50 41 nM) inducing apoptosis in diffuse large B-cell lymphoma cell lines R406 is utilized in research investigating hematologic malignancies and immune-mediated disorders
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