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Apexbio Technology LLC R406 (free base) 841290-80-0 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A58805.1

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R406 (free base CAS 841290-80-0) is a small molecule inhibitor of spleen tyrosine kinase (SYK) a non-receptor kinase expressed predominantly within hematopoietic cells As an ATP-competitive inhibitor R406 selectively binds SYK s ATP-binding domain thereby suppressing its kinase activity and downstream phosphorylation events (IC50 41 nM) In mast cells R406 inhibits Fc receptor-driven degranulation with an EC50 value of 56-64 nM In diffuse large B-cell lymphoma models it blocks SYK-dependent B-cell receptor signaling through impaired autophosphorylation at sites Y525/Y526 resulting in apoptosis This compound is orally bioavailable and serves as a research tool for hematologic malignancies and autoimmune diseases

Catalog No. 50-000-61864


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