Apexbio Technology LLC R428 1037624-75-1 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A83295.1

R428 (CAS 1037624-75-1) is a potent selective inhibitor of the receptor tyrosine kinase Axl demonstrating an IC50 of 14 nM In comparison to related kinases such as Abl Mer Tyro3 InsR EGFR HER2 and PDGFR R428 displays greater than 50-fold selectivity for Axl By inhibiting Axl catalytic function R428 disrupts downstream intracellular signaling pathways including Akt phosphorylation cellular invasion pro-inflammatory cytokine production angiogenesis and epithelial-mesenchymal transition mediator expression (e g Snail) Preclinical studies utilizing animal xenograft tumor models indicate its capacity to reduce metastatic tumor burden and extend survival both alone and combined with cisplatin R428 is orally bioavailable and represents a valuable tool for cancer research targeting Axl-driven pathogenesis

Catalog No. 50-000-61708