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Abcam R428 (BGB324), A x L inhibitor, 25MG
Supplier: Abcam AB14136425MG
MW 506.6 Da, Purity >98%. Potent and selective inhibitor of AXL kinase (IC₅₀ = 14 nM). Overcomes chemotherapy resistance to various agents in multiple cancer models. Suppresses myeloid cell activation and function. AXL inhibition combined with PD-1 blockade shows potent synergistic anti-tumor effects. Greater than 100-fold selective for AXL versus ABL. Selective (50-100-fold) versus Mer and Tyro3 in cell-based assays. Highly selective for AXL versus InsR, EGFR, HER2, and PDGFRbeta in cell-free assays.
The product is subject to the following: Abcam Restricted Use Statement
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