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Apexbio Technology LLC R788 disodium 1025687-58-4 5mg
Supplier: Apexbio Technology LLC A83325
R788 disodium (CAS 1025687-58-4) is a prodrug of the active metabolite R406 a selective inhibitor of spleen tyrosine kinase (Syk) Syk mediates signaling downstream of activated Fc and B-cell receptors (BCR) In vitro R406 suppresses constitutive and ligand-stimulated BCR signaling in diffuse large B-cell lymphoma (DLBCL) lines by inhibiting Syk autophosphorylation (SYK525/526) and associated phosphorylation of BLNK inducing apoptosis In vivo R788 reduces malignant B-cell proliferation and tumor progression in E -TCL1 mice Clinically R788 has shown utility in rheumatoid arthritis improving therapeutic response rates in phase II trials
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