Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 501976129

STEMCELL Technologies R848, Size: 50 mg
SDP

Catalog No. 501976129
Encompass

Modify immune responses by mimicking the pathogen-associated molecular patterns that activate immune cells through TLR7 and TLR8 with R848, an agonist of Toll-like receptors (TLRs) 7 and 8. This immune modulator targets osteoclast precursors and inhibits their differentiation into osteoclasts via TLR7 (Miyamoto et al. Cytotechnology, 2012); and induces myeloid differentiation of CD34+ hematopoietic progenitor cells (Sioud et al. J Mol Biol, 2006). R848 is also used in immunology research to trigger the activation of human B cells (Bishop et al. J Immunol, 2000); induce expression of IL-12 and IFN-ɣ in mouse and human peripheral blood cell cultures (Wagner et al. Cell Immunol, 1999); and suppress HIV-1 replication in monocytes (Nian et al. BMC Infect Dis, 2012). R848 is supplied as a crystalline solid with ≥98% purity; Molecular weight 314.4 g/mol; CAS Number 144875-48-9. Visit STEMCELL.com for more information and related products.

Catalog No. 50-197-6129 Supplier STEMCELL Technologies Supplier No. 73784
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

Modify immune responses by mimicking the pathogen-associated molecular patterns that activate immune cells through TLR7 and TLR8 with R848, an agonist of Toll-like receptors (TLRs) 7 and 8. This immune modulator targets osteoclast precursors and inhibits their differentiation into osteoclasts via TLR7 (Miyamoto et al. Cytotechnology, 2012); and induces myeloid differentiation of CD34+ hematopoietic progenitor cells (Sioud et al. J Mol Biol, 2006). R848 is also used in immunology research to trigger the activation of human B cells (Bishop et al. J Immunol, 2000); induce expression of IL-12 and IFN-ɣ in mouse and human peripheral blood cell cultures (Wagner et al. Cell Immunol, 1999); and suppress HIV-1 replication in monocytes (Nian et al. BMC Infect Dis, 2012). R848 is supplied as a crystalline solid with ≥98% purity; Molecular weight 314.4 g/mol; CAS Number 144875-48-9. Visit STEMCELL.com for more information and related products.

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.