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Medchemexpress LLC (Rac)-Razpipadon | 1643462-93-4 | 97.1% | C19H17F2N3O4 | 100 MG
Supplier: Medchemexpress LLC HY141495100MG
(Rac)-Razpipadon, also known as PW0464, is a nanomolar potent, complete G protein biased ligand. It functions as a noncatechol D1R agonist, demonstrating an EC50 of 5.8 nM (Gs-cAMP). This compound exhibits complete G protein bias, with no activity observed for D1R-mediated β-arrestin recruitment.
- Exhibits agonist activity at D5R with an EC50 of 12 nM in HEK293 cells.
- Demonstrates agonist activity at wild type human D1R with an EC50 of 5.3 nM in HEK293 cells.
- Forms bonds with S1985.42 and S2025.46 via its fluorine atom.
- Elicits complete G protein bias, showing no activity for D1R-mediated β-arrestin recruitment.
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