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AG Scientific Inc Radicicol, 5 MG
Supplier: AG Scientific Inc R11305MG
Radicicol is a macrocyclic antifungal antibiotic that inhibits protein tyrosine kinase. Isolated from Monocillium nordinii, it binds to and inhibits Hsp90 at very low concentrations (20nM). Heat shock Protein 90(Hsp90), is a molecular chaperone that mediates the folding of a number of oncogenic proteins, it is an attractive target for inhibiton by anticancer agents.Radicicol binds to a highly conserved pocket in the Hsp90 protein and inhibits the intrinsic ATPase activity of Hsp90. Radicicol induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2.CAS Number: 12772-57-5Molecular Weight: 364.78 DaChemical Formula: C18H17ClO6Solubility: 20 mg/mL DMSO and 10 mg/mL methanolStorage Temperature: -20CResearch or further manufacturing use only, not for food or drug use.
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