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Medchemexpress LLC Raloxifene hydrochloride | 82640-04-8 | 99.8% | 510.04 | 25 MG
Supplier: Medchemexpress LLC 25MGHY13738AR
Raloxifene hydrochloride is a second-generation, selective, and orally active estrogen receptor modulator. It exhibits estrogen-agonistic effects on bone and lipid metabolism, while demonstrating estrogen-antagonistic effects on uterine endometrium and breast tissue.
- Activates TGF beta 3 promoter as a full agonist
- Inhibits estrogen response element-containing vitellogenin promoter expression
- Acts as a potent uncompetitive inhibitor of human liver aldehyde oxidase
- Functions as a noncompetitive inhibitor of aldehyde oxidase-catalyzed reduction reactions
- Decreases viability in mouse mammary carcinoma cells
- Demonstrates estrogenic activity on bone resorption and serum cholesterol in ovariectomized rats
- Increases bone mineral density in ovariectomized rats
- Reduces serum cholesterol in ovariectomized rats
- Suppresses tumor volumes and decreases lymph node metastasis in mice
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