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Apexbio Technology LLC Raltegravir (MK-0518) 518048-05-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A40735.1
Raltegravir (MK-0518) is an inhibitor targeting HIV-1 integrase an enzyme essential for viral genome integration into host cellular DNA This compound disrupts the integrase-catalyzed strand transfer step during viral replication thereby hindering productive HIV infection In vitro studies demonstrate that Raltegravir inhibits replication of multidrug-resistant strains and isolates utilizing either CCR5 or CXCR4 coreceptors Its reported IC50 values typically range within the low nanomolar concentration levels Raltegravir is widely employed as a tool molecule in antiviral mechanism research drug resistance assays and preclinical HIV therapy-focused drug screening studies
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