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Medchemexpress LLC Ramipril (HOE-498) | 87333-19-5 | 99.4% | 1 ML
Supplier: Medchemexpress LLC HYB027910MM/1ML
Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5 nM. It enhances the activity of ACE-associated CK2 and the phosphorylation of ACE Ser1270 in cultured endothelial cells. Chronic in vivo administration to rats significantly reduces LPS-induced apoptosis. It inhibits systolic blood pressure (SBP) with an IC50 of 1.97 mg/kg in spontaneously hypertensive rats (SHR).
- Potent angiotensin-converting enzyme (ACE) inhibitor
- Enhances ACE-associated CK2 activity
- Reduces LPS-induced apoptosis in rats
- Inhibits systolic blood pressure (SBP)
- For research use only
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