Apexbio Technology LLC Rapamycin (Sirolimus) 53123-88-9 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A81675.1

Rapamycin (Sirolimus) is an antifungal antibiotic originally isolated from the bacterium Streptomyces hygroscopicus It serves as an immunosuppressant agent widely employed in research to prevent graft rejection by inhibiting T-cell activation and proliferation Rapamycin exerts its biological function by binding intracellularly to FK-binding protein 12 (FKBP12) forming a rapamycin-FKBP12 complex that inhibits mTOR (mechanistic target of rapamycin) a serine-threonine kinase involved in cell cycle control cell growth and metabolism This compound is often used experimentally to study mTOR signaling pathways in cancer biology and immunological research frequently showing inhibitory activities with an IC50 range of approximately 0 1-20 nM in various cell-based assays

Catalog No. 50-000-62099