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AdipoGen Rasfonin
Supplier: AdipoGen AGCN20173C500
Chemical. CAS 303156-68-5. Formula C25H38O6. MW 434.6. Isolated from Trichurus sp. Selective apoptosis inducer in ras-dependent cells. Autophagy Akt-dependent, apoptosis and necroptosis inducer in renal cancer cell lines. Induces death of ras-mutated pancreatic tumor Panc-1 cells in vitro and in vivo. Robust inhibitor of pancreatic cancers with the K-ras mutation. Reduced Sos1 expression and depressed Ras-MAPK activity.
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