Invitrogen™ Rat Leptin Receptor (aa 577-594) Synthetic Peptide

Catalog No.	Quantity
PEP014	50 μg

Catalog No. PEP014 Supplier Invitrogen™ Supplier No. PEP014

Description

Synthetic Peptide

PEP-014 is an 18 amino acid (amino acids 577-594) synthetic peptide whose sequence is from the extracellular domain of the leptin receptor (OB-R). The sequence of this peptide is (amino to carboxy terminus): K-E-I-Q-W-K-T-H-E-V-F-D-A-K-S-K-S-A This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and leptin receptor (OB-R), catalog # PA1-053. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody. Reconstitute with 0.1 mL of distilled water.

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.

Specifications

• Gene ID (Entrez): 24536
• Species: Rat
• Purification Method: purified
• Accession Number: Q62959
• Common Name: Leptin Receptor
• Concentration: 0.5 mg/mL
• Content And Storage: -20°C. Avoid freeze-thaw cycles.
• Description: Synthetic Peptide
• Format: Lyophilized
• Formulation: Peptide with no preservative
• For Use With (Application): Control
• Gene Alias: B219; CD antigen CD295; CD295; CD295 antigen; db; diabetes; Fa; HuB219; HuB219.2; LEPR; LEP-R; Leprb; LEPRD; LEPROT; leptin receptor; Leptin receptor (fatty); leptin receptor gene-related protein; Modb1; OB receptor; obese-like; obl; Obr; OB-R; OB-RGRP
• Gene Symbol: Lepr
• Lyophilized: Yes
• Preservative: No preservative
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Sequence: K - E - I - Q - W - K - T - H - E - V - F - D - A - K - S - K - S - A