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Invitrogen™ Rat Notch-2 ELISA Kit

Rat Notch-2 quantitates rat Notch-2 in serum, plasma, supernatant.

Manufacturer:  Invitrogen™ ERA45RBX5

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Catalog No. ERA45RBX5


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Description

Description

Rat Notch-2 quantitates rat Notch-2 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat Notch-2.

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
Specifications

Specifications

ELISA
AGS2; AI853703; HJCYS; hN2; Motch B; N2; N2ECD; N2ICD; Neurogenic locus notch homolog protein 2; notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; Notch gene homolog 2; Notch homolog 2; NOTCH2
HRP
Q9QW30
Research Use Only
2°C to 8°C
4 hr 45 min
<12%
5 x 96 Tests
0.14 ng/mL
Colorimetric Microplate Reader
Biotin
0.14 to 25 ng/mL
Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
Supernatant, 50 µL; Plasma, 50 µL; Serum, 50 µL
1 hr 20 min
NOTCH2
<10%
Serum, Plasma, Supernatant
NOTCH2
SDS
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