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Gibco™ Rat Oncostatin M Recombinant Protein, PeproTech®

Catalog No. p-7246386
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Catalog No. Quantity
40036100UG 100 μg
400-36-10UG 10 μg
400-36-1MG 1 mg
40036250UG 250 μg
400-36-2UG 2 μg
40036500UG 500 μg
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Catalog No. 40036100UG Supplier Gibco™ Supplier No. 40036100UG
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Description

Recombinant Protein

Recombinant Rat Oncostatin M is a 24.4 kDa protein, containing 215 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q65Z15
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 289747
Molecular Weight (g/mol) 24.4 kDa
Name Rat Oncostatin M
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias MGC20461; OncoM; oncostatin M; oncostatin-M; OSM
Common Name Oncostatin M
Gene Symbol OSM
Biological Activity Assay 1: Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 is 3.0-5.0 ug/ml Assay 2: Determined by its ability to inhibit Alkaline phosphatase activity of differentiated MC3T3 E1 cells.
Conjugate Unconjugated
Recombinant Recombinant
Sequence MKRGCSSSSP KLLSQLKSQA NITGNTASLL EPYILHQNLN TLTLRAACTE HPVAFPSEDM LRQLSKPDFL STVHATLGRV WHQLGAFRQQ FPKIQDFPEL ERARQNIQGI RNNVYCMARL LHPPLEIPEP TQADSGTSRP TTTAPGIFQI KIDSCRFLWG YHRFMGSVGR VFEEWGDGSR RSRRHSPLWA WLKGDHRIRP SRSSQSAMLR SLVPR
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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