STEMCELL Technologies Rat Recombinant TNF-alpha, Size: 50 µg

Supplier:  STEMCELL Technologies 78124.1

Use tumor necrosis factor-alpha (TNF-α) to activate the NF-κB, MAPK, and PI3K/AKT pathways. TNF-α is a pro-inflammatory cytokine that stimulates the expression of E- and P-selectins, facilitating adhesion of neutrophils, monocytes, and memory T cells to activated platelets and endothelial cells (Zelová & Hošek. Inflamm Res, 2013). It also stimulates anti-tumor immunosuppressive responses, vasodilation, and edema formation. TNF-α is primarily produced by activated T cells and macrophages in response to inflammation and infectious conditions. Many other cell types have been shown to produce TNF-α, such as B cells, NK cells, mast cells, neutrophils, dendritic cells, endothelial cells, cardiomyocytes, and fibroblasts. Rat recombinant TNF-α from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 0.05 ng/mL; endotoxin levels verified ≤ 0.2 EU/μg protein. Alternative names: Cachectin, Cytotoxin, Differentiation-inducing factor, DIF, Necrosin, TNFA, TNFSF2, Tumor necrosis factor.

Catalog No. 50-197-6522