Invitrogen™ Rat VAMP2 (aa 1-18) Synthetic Peptide

Catalog No.	Quantity
PEP101	50 μg

Catalog No. PEP101 Supplier Invitrogen™ Supplier No. PEP101

Description

Synthetic Peptide

PEP-101 is a 18 amino acid synthetic peptide whose sequence corresponds to amino acid residues 1-18 of rat VAMP-2. The sequence of this peptide is (amino to carboxy terminus): M (1)-S-A-T-A-A-T-V-P-P-A-A-P-A-G-E-G-G (18) This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat VAMP-2, catalog # PA1-766. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 0.1 mL of distilled water.

The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered. It is suggested that VAMP-2 is a resident protein of the insulin-sensitive glucose transporter type 4 (GLUT4) compartment and that it is required for GLUT4 vesicle incorporation into the cell surface in response to insulin.

Specifications

• Gene ID (Entrez): 24803
• Species: Rat
• Purification Method: purified
• Accession Number: P63045
• Common Name: VAMP2
• Concentration: 0.5 mg/mL
• Content And Storage: -20°C. Avoid freeze-thaw cycles.
• Description: Synthetic Peptide
• Format: Lyophilized
• Formulation: Peptide with no preservative
• For Use With (Application): Control
• Gene Alias: RATVAMPB; RATVAMPIR; SYB; SYB2; Syb-2; sybII; Synaptobrevin; synaptobrevin 2; Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2); synaptobrevin II; synaptobrevin-2; vamp; Vamp2; VAMP-2; vesicle associated membrane protein 2; vesicle-associated membrane 2; Vesicle-associated membrane protein (synaptobrevin 2); vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2)
• Gene Symbol: VAMP2
• Lyophilized: Yes
• Preservative: No preservative
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Sequence: M(1)-S-A-T-A-A-T-V-P-P-A-A-P-A-G-E-G-G(18)

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov