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Apexbio Technology LLC RBC8 361185-42-4 50mg
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Catalog No. 5000089500
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RBC8 (CAS 361185-42-4) is a selective small-molecule inhibitor of Ral GTPases targeting both RalA and RalB which are Ras-related GTPases implicated in tumor growth and metastasis In cellular assays RBC8 suppresses Ral-dependent NSCLC cell lines H2122 and H358 with IC50 values of 3 4 M and 3 5 M respectively In live cells RBC8 reduces RalA activity and selectively inhibits cellular spreading in wild-type mouse embryonic fibroblasts (MEFs) but not in CAV1-deficient MEFs In vivo daily intraperitoneal administration of RBC8 significantly inhibits tumor growth in H2122 and H358 xenografts RBC8 is a valuable research tool for elucidating Ral GTPase-mediated pathways in cancer biology

Catalog No. 50-000-89500 Supplier Apexbio Technology LLC Supplier No. B488450
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RBC8 (CAS 361185-42-4) is a selective small-molecule inhibitor of Ral GTPases targeting both RalA and RalB which are Ras-related GTPases implicated in tumor growth and metastasis In cellular assays RBC8 suppresses Ral-dependent NSCLC cell lines H2122 and H358 with IC50 values of 3 4 M and 3 5 M respectively In live cells RBC8 reduces RalA activity and selectively inhibits cellular spreading in wild-type mouse embryonic fibroblasts (MEFs) but not in CAV1-deficient MEFs In vivo daily intraperitoneal administration of RBC8 significantly inhibits tumor growth in H2122 and H358 xenografts RBC8 is a valuable research tool for elucidating Ral GTPase-mediated pathways in cancer biology

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