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Medchemexpress LLC Rebastinib (DCC-2036) | 1020172-07-9 | 99.84% | 200 MG
SDP

Catalog No. 5000338944
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Rebastinib is an orally active, non-ATP-competitive inhibitor that targets Bcr-Abl, including its wild-type and T315I mutant forms. It also demonstrates inhibitory activity against SRC, KDR, FLT3, and Tie-2, while showing minimal activity against c-Kit.

  • Orally active.
  • Non-ATP-competitive inhibition of Bcr-Abl.
  • Effective against wild-type and T315I mutant Bcr-Abl.
  • Inhibits other kinases such as SRC, KDR, FLT3, and Tie-2.
  • Demonstrates low activity toward c-Kit.
  • Potently inhibits both inactive and active forms of ABL1.
  • Effective against several common TKI-resistant Bcr-Abl mutants.
  • Inhibits proliferation of cells expressing Bcr-Abl and Ph+ cell lines.
  • Reduces autophosphorylation of Bcr-Abl and phosphorylation of STAT5.

Catalog No. 50-003-38944 Supplier Medchemexpress LLC Supplier No. HY13024200MG
May include imposed supplier surcharges.
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Rebastinib is an orally active, non-ATP-competitive inhibitor that targets Bcr-Abl, including its wild-type and T315I mutant forms. It also demonstrates inhibitory activity against SRC, KDR, FLT3, and Tie-2, while showing minimal activity against c-Kit.

  • Orally active.
  • Non-ATP-competitive inhibition of Bcr-Abl.
  • Effective against wild-type and T315I mutant Bcr-Abl.
  • Inhibits other kinases such as SRC, KDR, FLT3, and Tie-2.
  • Demonstrates low activity toward c-Kit.
  • Potently inhibits both inactive and active forms of ABL1.
  • Effective against several common TKI-resistant Bcr-Abl mutants.
  • Inhibits proliferation of cells expressing Bcr-Abl and Ph+ cell lines.
  • Reduces autophosphorylation of Bcr-Abl and phosphorylation of STAT5.

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