The 29F.1A12™-CP178 monoclonal antibody is a recombinant chimeric antibody that reacts with mouse PD-1 (CD279). Its constant region has been switched from rat IgG2a to mouse IgG1, while retaining identical variable domain sequences. This antibody is designed to target PD-1, a cell surface receptor involved in inhibiting T-cell activation and playing key roles in peripheral tolerance.
- Purified from CHO cell supernatant in an animal-free facility
- Purification by protein G
- Formulated in PBS, pH 7.0, without stabilizers or preservatives
- Isotype: mouse IgG1, κ
- Molecular weight: 150 kDa
- Unconjugated
- Endotoxin ≤0.5 EU/mg (≤0.0005 EU/µg)
- Purity ≥95% by SDS-PAGE
- Sterility by 0.2 µm filtration
- Reported applications include in vivo blocking of PD-1/PD-L signaling and in vitro PD-1 neutralization