R&D Systems™ Recombinant Human TIM-3 Fc Chimera Protein

Catalog No. 2365TM050

Supplier: R&D Systems™ 2365TM050

Description

Extensive quality control produces lot-to-lot consistency that instills confidence in results and ensures reproducibility. Applications: Binding Activity

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Galectin-9 (Catalog # 2045-GA ) at 500 ng/mL can bind Recombinant Human TIM-3 Fc Chimera with an apparent Kd <30 nM.

Specifications

• Accession Number: Q8TDQ0
• For Use With (Application): Binding Activity
• Formulation: Lyophilized from a 0.2 μm filtered solution in PBS.
• Gene ID (Entrez): 84868
• Molecular Weight (g/mol): M.W. (Observed): 66 kDa, reducing conditions; M.W. (theoretical): 46.4 kDa (monomer)
• Name: TIM-3 Fc Chimera
• Quantity: 50 μg
• Source: Mouse myeloma cell line, NS0-derived human TIM-3 protein Human TIM-3 (Ser22-Arg200) (N-terminus) Accession # Q8TDQ0 IEGRMD Human IgG1 (Pro100-Lys330) (C-terminus)
• Storage Requirements: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20°C to -70°C as supplied. 3 months, -20°C to -70°C under sterile conditions after reconstitution.
• Structural Form: Disulfide-linked homodimer
• Endotoxin Concentration: <0.10 EU / 1 μg of the protein by the LAL method.
• Gene Alias: CD366, FLJ14428, HAVcr-2, HAVCR2, hepatitis A virus cellular receptor 2, kidney injury molecule-3, KIM-3, SPTCL, T cell immunoglobulin mucin 3, T cell immunoglobulin mucin-3, T-cell immunoglobulin and mucin domain-containing protein 3, TIM 3, Tim-3, TIM3, TIM3 T-cell membrane protein 3, TIMD3, TIMD-3, TIMD3KIM-3
• Gene Symbol: HAVCR2
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
• Purity or Quality Grade: >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining.
• Protein: TIM-3