R&D Systems™ Recombinant Mouse TEM8/ANTXR1 Fc Chimera Protein

Description

Anthrax toxin receptor 1 (ANTXR1), also known as Tumor endothelial marker 8 (TEM8), is a glycoprotein of the Anthrax Toxin Receptor family that is expressed by endothelial cells

• TEM8/ANTXR1 has been implicated in tumor angiogenesis, as its expression has been shown to up-regulate in tumor blood vessels and is characterized as a tumor endothelial marker
• TEM8/ANTXR1 was reported to be an amplifier of Wnt signaling in tumor microenvironment
• Additionally, TEM8/ANTXR1 serves as the receptor for Seneca Valley virus, an oncolytic picornavirus affecting neuroendocrine cancers
• Mouse TEM8/ANTXR1 shares 99% and 100% aa identity with human and rat TEM8/ANTXR1, respectively, within the extracellular domain

Specifications

• Accession Number: Q9CZ52
• For Use With (Application): Bioactivity
• Gene ID (Entrez): 84168
• Molecular Weight (g/mol): 60 kDa
• Purification Method: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining
• Quantity: 50 μg
• Source:

  Mouse myeloma cell line, NS0-derived mouse TEM8/ANTXR1 protein

  Mouse TEM8/ANTXR1 (Glu31-Ser319) Accession # Q9CZ52IEGRMDPMouse IgG2a (Glu98-Lys330)N-terminus C-terminus

• Storage Requirements: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
• Endotoxin Concentration: <0.10 EU per 1 μg of the protein by the LAL method
• Conjugate: Unconjugated
• Reconstitution: Reconstitute at 500 μg/mL in PBS
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose