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Medchemexpress LLC Redafamdastat | 1020315-31-4 | 98.86% | C23H20F3N5O2 | 100 MG
Supplier: Medchemexpress LLC HY14376100MG
Redafamdastat (PF-04457845) is a highly efficacious and selective FAAH inhibitor, functioning through a covalent, irreversible mechanism by carbamylating the active-site serine nucleophile of FAAH. It demonstrates exquisite selectivity for FAAH over other members of the serine hydrolase superfamily, completely inhibiting FAAH in human and mouse membrane proteomes without affecting off-targets even at high concentrations. Oral administration has shown efficacy comparable to naproxen in a rat model of inflammatory pain, significantly inhibiting mechanical allodynia.
- Highly efficacious and selective FAAH inhibitor
- Inhibits FAAH through a covalent, irreversible mechanism
- Shows exquisite selectivity for FAAH over other serine hydrolases
- Completely inhibits FAAH in human and mouse membrane proteomes
- Effective in reducing inflammatory pain in vivo
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