Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000063997

Apexbio Technology LLC Regorafenib monohydrate 1019206-88-2 100mg
SDP

Supplier:  Apexbio Technology LLC A3751100

Encompass_Preferred

Regorafenib monohydrate (CAS 1019206-88-2) is a multitargeted tyrosine kinase inhibitor that suppresses numerous intracellular and membrane receptor tyrosine kinases (RTKs) including VEGFR (types 1-3) PDGFR- FGFR-1 RET TIE2 c-KIT Raf-1 and BRAF (wild-type and V600E mutant) It inhibits angiogenic RTKs such as VEGFR-2 with IC50 values ranging from approximately 4 2 to 46 nM and oncogenic RTKs like c-KIT and RET with IC50 values around 1 5 to 28 nM Regorafenib demonstrates antiproliferative activity in vitro (mean IC50 1 M) and reduces tumor progression in xenograft animal models supporting its use in cancer research involving breast colorectal thyroid pancreatic cancers melanoma and gastrointestinal stromal tumors

Catalog No. 50-000-63997


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.