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Medchemexpress LLC (rel)-AR234960 | 1408311-94-3 | HY-120006A | 98.95% | 555.62 | 10 MG
Supplier: Medchemexpress LLC 10MGHY120006A
(rel)-AR234960 is a selective and competitive agonist of the G protein-coupled receptor MAS. It activates the downstream ERK1/2 signaling pathway, leading to the expression of connective tissue growth factor (CTGF) and its downstream collagen subtype genes. This compound promotes collagen synthesis in cardiac fibroblasts via the MAS-ERK1/2-CTGF pathway and exacerbates extracellular matrix remodeling. It regulates the expression of cardiac fibrosis-related genes and can be utilized in heart failure research.
- Selective and competitive MAS receptor agonist
- Activates ERK1/2 signaling pathway
- Induces CTGF and collagen gene expression
- Promotes collagen synthesis in cardiac fibroblasts
- Regulates cardiac fibrosis-related genes
- Useful in heart failure research
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