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  6. Remacemide hydrochloride, Tocris Bioscience™

Remacemide hydrochloride, Tocris Bioscience™

Catalog No. 162210
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Catalog No. Quantity
16-221-0 10 mg
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Catalog No. 16-221-0 Supplier R&D Systems Supplier No. 1622/10
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Description

NMDA antagonist; blocks ion channel and allosteric modulatory site

Remacemide hydrochloride is an non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC50 = 8 - 68 mM). Remacemide hydrochloride is anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na+ channels (IC50 = 161 mM). In an animal model of Huntington's disease, extends survival and delays disease; this effect is more pronounced when combined with Coenzyme Q10 (Cat. No. 3003)

Chemical Identifiers

CAS 111686-79-4
Molecular Formula C17H21ClN2O
Molecular Weight (g/mol) 304.818
InChI Key HYQMIUSWZXGTCC-UHFFFAOYSA-N
Synonym remacemide hydrochloride, remacemide hcl, remacemide hydrochloride usan, 2-amino-n-1,2-diphenylpropan-2-yl acetamide hydrochloride, +--2-amino-n-1-methyl-1,2-diphenylethyl acetamide monohydrochloride, 2-amino-n-1-methyl-1,2-diphenylethyl acetamide hydrochloride, acetamide, 2-amino-n-1-methyl-1,2-diphenylethyl-, +/--cas, dsstox_cid_25683, dsstox_rid_81056, dsstox_gsid_45683
PubChem CID 60510
IUPAC Name 2-amino-N-(1,2-diphenylpropan-2-yl)acetamide;hydrochloride
SMILES CC(CC1=CC=CC=C1)(C2=CC=CC=C2)NC(=O)CN.Cl

Specifications

Quantity 10 mg
Formula Weight 304.82
Percent Purity >99%
Chemical Name or Material Remacemide hydrochloride

Safety and Handling

Recommended Storage Desiccate at Room Temperature
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