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Apexbio Technology LLC RepSox 446859-33-2 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A37545.1

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RepSox (CAS 446859-33-2) is a selective small-molecule inhibitor of TGF receptor-1 (TGF R-1) a serine/threonine kinase receptor involved in regulating tumor transformation cell proliferation and differentiation via TGF signaling pathways RepSox inhibits TGF R-1 activity with an IC50 of 23 nM thereby modulating downstream signaling events In cellular studies RepSox facilitated reprogramming of mouse embryonic fibroblasts (MEFs) into induced pluripotent stem cells (iPSCs) by functionally substituting for Sox2 Due to its capacity to significantly alter expression profiles linked to TGF signaling RepSox serves as a useful tool in stem cell research and cellular reprogramming studies

Catalog No. 50-000-64311


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