STEMCELL Technologies RepSox, Size: 10 mg

Supplier:  STEMCELL Technologies 73794

RepSox is a cell-permeable, selective inhibitor of the TGF-β type 1 receptor (TGFβRI) ALK5 (IC₅₀ = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively; Gellibert et al.). This inhibitor demonstrates less potent activity (IC₅₀ > 16 µM) against 9 related kinases, including p38 MAPK and GSK3 (Gellibert et al.).REPROGRAMMING· Enhances reprogramming of mouse embryonic fibroblasts (MEFs) that have been transduced with OCT4, KLF4, and c-MYC (Ichida et al.; Subramanyam et al.). · Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, Valproic Acid, Forskolin, SP600125, Gö6983 and Y-27632 (Hu et al.). DIFFERENTIATION · Alone or in combination with Forskolin, Dexamethasone, and Nicotinamide, induces differentiation of human pancreatic progenitor cells into insulin-producing cells (Kunisada et al.; Rezania et al.).

Catalog No. 50-197-6131

Safety and Handling

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