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Medchemexpress LLC Resminostat hydrochloride | 1187075-34-8 | 99.7% | 385.87 | 1 ML
Supplier: Medchemexpress LLC HY14718A10MM/1ML
Resminostat hydrochloride is a potent inhibitor of HDAC1, HDAC3, and HDAC6, demonstrating mean IC50 values of 42.5, 50.1, and 71.8 nM, respectively. It exhibits less potent activity against HDAC8, with an IC50 of 877 nM. This compound is intended for research use only.
- Potent inhibitor of HDAC1, HDAC3, and HDAC6
- Induces histone acetylation in myeloma cells
- Inhibits cell growth and induces apoptosis in MM cells
- Modulates bcl-2 family proteins and inhibits Akt pathway signaling
- Exerts synergistic activity with anti-myeloma agents
- Inhibits cell growth in head and neck squamous cell carcinoma cell lines
- Synergistic effect with irradiation on HNSCC cell lines
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